NMN Sleep Quality Human Trial: Breakthrough Results for Aging Adults

A recent human trial has shown that the supplement nicotinamide mononucleotide (NMN) significantly improves sleep quality in middle-aged and older adults. This innovative study suggests that NMN could potentially help address sleep issues that are common in aging populations and contribute to overall health and well-being.

NMN improves sleep in middle age and older people

Are you tired of tossing and turning each night, struggling to get a good night's sleep? According to a groundbreaking human trial, a supplement called nicotinamide mononucleotide (NMN) could be the key to improving sleep quality in middle-aged and older adults. Published in the American Journal of Translational Medicine, the study provides compelling evidence that NMN has a significant impact on sleep and overall health.

Although NMN is not a magic bullet, it holds promise as a natural, science-backed supplement that could help middle-aged and older adults enjoy better sleep and enhanced quality of life. As more evidence emerges, NMN may soon become a staple in the daily regimen of those seeking to maintain good health and age gracefully.

The Study Design

This double-blind, placebo-controlled trial recruited 80 participants aged 45-75 years, randomly allocating them to two groups. The intervention group received a daily dosage of 300 mg NMN. While the control group received a placebo for 12 weeks. Researchers assessed sleep quality, daytime sleepiness, sleep efficiency. And other sleep-related parameters using validated questionnaires and actigraphy. A non-invasive method for monitoring sleep-wake patterns, both before and after the intervention.

Compelling Findings NMN and sleep quality

The results of the study showed that participants in the NMN group experienced significant improvements in sleep quality compared to the control group. They reported better sleep efficiency, fewer night-time awakenings, and reduced daytime sleepiness. Additionally, the improvements correlated with increased NAD+ levels. Suggesting that NMN effectively boosts NAD+ and may enhance sleep by addressing age-related declines in cellular function.

Results of the NMN studies that indicates that is improves sleep
Image taken from original study

Implications for Aging and Health

These findings carry significant implications for middle-aged and older adults, indicating that NMN could be an effective, safe intervention for sleep issues commonly associated with aging. Improved sleep can contribute to enhanced cognitive function, emotional well-being, and overall health.

Moreover, NMN has shown promise in other aspects of health and aging. Previous research has demonstrated that NMN supplementation can improve insulin sensitivity, reduce inflammation, and extend the lifespan of certain animals. While more research is needed to fully understand NMN's potential, these findings suggest that it could be a powerful tool for promoting health and longevity.

A Natural Solution for Better Sleep

The growing interest in NMN reflects a broader shift in society's approach to health. With an emphasis on natural, evidence-based interventions. With its potential to improve sleep quality and overall health. NMN may soon become an indispensable part of the daily routine for middle-aged and older adults. Importantly, this study highlights the need for further research into the molecular mechanisms underlying age-related sleep disturbances. As well as the long-term safety and efficacy of NMN supplementation.


In conclusion, the human trial conducted on the effects of NMN supplementation on sleep quality in middle-aged and older adults has shown significant potential for improving sleep and overall health. The trial's findings contribute to our understanding of the molecular mechanisms underlying age-related sleep disturbances. And encourage further exploration into the benefits of NMN supplementation. As we continue to advance our knowledge of aging and health, NMN may soon emerge as a vital component in the pursuit of better sleep and a healthier, more fulfilling life.

Another study on nmn and endurance can be found here.

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Lee, J., Kim, S. H., Lee, H. J., Park, K., Kang, S. W., & Kim, H. S. (2023). NMN Improves Sleep in Middle-Aged and Older Adults. American Journal of Translational Medicine. Retrieved from https://ajtm.journals.publicknowledgeproject.org/index.php/ajtm/article/view/2535/2438

Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., ... & Imai, S. I. (2016). Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metabolism, 24(6), 795-806.

Uddin, G. M., Youngson, N. A., Sinclair, D. A., & Morris, M. J. (2016). Head to Head Comparison of Short-Term Treatment with the NAD(+) Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice. Frontiers in Pharmacology, 7, 258.

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